We study niche signals, polyploidy
and regeneration
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Niche Signals in Tissue Regeneration
Niche signals, a variety of molecular cues provided by the microenvironment, are fundamental in regulating stem cell behavior, tissue homeostasis, and regeneration. These signals ensure that stem cells receive the appropriate instructions to proliferate, differentiate, or remain quiescent, depending on the physiological needs of the tissue.
The Role of Polyploidy in Liver Regeneration
Polyploidy, a condition where cells contain more than two sets of chromosomes, is a characteristic feature of hepatocytes, the primary cells of the liver. This unique aspect of the liver is linked to its regenerative abilities, though during disease states, polyploid hepatocytes may lose their proliferative capacity.
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